منابع مشابه
SUMO wrestling with Ras
This review discusses our current understanding of the small ubiquitin-like modifier (SUMO) pathway and how it functionally intersects with Ras signaling in cancer. The Ras family of small GTPases are frequently mutated in cancer. The role of the SUMO pathway in cancer and in Ras signaling is currently not well understood. Recent studies have shown that the SUMO pathway can both regulate Ras/MA...
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There is a growing appreciation among economists of the need to better understand the role that corruption plays in real-world economies. Although some have argued that it can be welfare enhancing (Nathaniel Leff, 1964), most commentators believe that a willingness to accept bribes (or similar forms of corruption) in either the public or the private sector reduces economic ef ciency (Andrei Sh...
متن کاملSUMO wrestling with Drp1 at mitochondria.
Mitochondria undergo dynamic fission and fusion events, and disruptions in this balance can lead to cellular dysfunction or death. New work by Henley and colleagues identifies a key role for the SUMO protease SENP3 and its target Drp1, a key mediator of mitochondrial fission, in ischaemia. The term mitochondrion is derived from the Greek mitos (thread) and khondrion (small grain), emphasizing t...
متن کاملSUMO Modification: Wrestling with Protein Conformation
SUMO modification of human thymine-DNA glycosylase facilitates the processing of base excision repair substrates by an unusual mechanism: while leaving the catalytic center unaffected, it induces product release by eliciting a conformational change in the enzyme.
متن کاملFighting polyglutamine disease by wrestling with SUMO.
Spinobulbar muscular atrophy (SBMA) is an X-linked disease characterized by degeneration of motor neurons, muscle atrophy, and progressive weakness. It is caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR), a transcription factor that is activated upon hormone binding. The polyQ expansion in AR causes it to form intracellular aggregates and impairs transcriptional activit...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2010
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2010.162